Korean Journal of Urology  1996;37(12):1327-1332

Effect of Intralesional Interleukin-2 on Murine Bladder Tumor.

Hyeon Hoe KIM 1 ; Eun Sik LEE ; Sang Jin YOON ; Moon Ki JO ; Chongwook LEE

Affiliations

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Keywords

bladder tumor; interleukin-2

Country

Republic of Korea

Language

Korean

Abstract

PURPOSE: We tried to evaluate the anticancer effect of intralesional interleukin-2 on murine bladder tumor. MATERIALS AND METHODS: In vitro direct anticancer effect of interleukin-2 upon MBT-2 cells was examined using MTT colorimetric assay in various concentration of human recombinant interleukin-2. Also in vivo study was carried out measuring the tumor implantation rates and growth of the implanted tumors on C3H/He mice receiving six consecutive injections of various concentrations of interleukin-2. RESULTS: No definite direct anticancer effect was found on in vitro study. Also, the tumor implantation rate and growth of the implanted tumors were similar whether interleukin-2's were injected or not. CONCLUSION: Intralesional injection of interleukin-2 does not seem to be effective upon murine bladder tumor.