The Journal of the Korean Society for Transplantation  2010;24(2):73-79

doi:10.4285/jkstn.2010.24.2.73

Prophylaxis for Hepatitis B Core Antibody-Positive Donors after Liver Transplantation.

Hee Yeon KIM 1 ; Jong Young CHOI

Affiliations

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Keywords

Hepatitis B core antibody positive donor; Prophylaxis; De novo hepatitis B; Liver transplantation

Country

Republic of Korea

Language

Korean

Abstract

The growing shortage of organs for orthotopic liver transplantation (OLT) has led to an expanded donor pool with the use of marginal grafts. Recipients who receive liver grafts from HBsAg-negative, anti-HBc positive donors have an increased risk of developing de novo hepatitis B infection. This review covers several issues in liver transplantation using hepatitis B core antibody-positive donors: (1) the mechanism of de novo hepatitis B infection, (2) high risk groups, (3) prophylactic regimens and (4) clinical significance and a proposal for patients in Korea.