Journal of International Pharmaceutical Research 2016;43(4):658-664

doi:10.13220/j.cnki.jipr.2016.04.013

Epigenetics-based anticancer drugs:research advances

Ming WANG ; Xue LI ; Ziling WANG

Keywords

epigenetics; neoplasms; DNA methyl transferase inhibitors; histone deacetylase inhibitor

Country

China

Language

Chinese

Abstract

In recent years,with the completion of the Human Genome Project and the development of mapping the Human Ge?nome Methylation Variable Site Map Plan,research on epigenetics and the generation and deveopment of cancer,epigenetic treatment drugs,especially the successful clinical application of the DNA methyltransferase and histone deacetylation inhibitors in the treatment of cancer patients,epigenetic has becoming a hot spot. This article reviews the recent progress in pharmacological action of epigenetics-based anticancer drugs,it may provide some new ideas to the therapy and fundamental research of cancer.