Korean Journal of Obstetrics and Gynecology  1997;40(5):1037-1043

The Effects of Conjugated Equine Estrogens Plus Dydrogesterone on Lipid and Bone Metabolism inPostmenopausal Women.

Soo Yong CHOUGH 1 ; Jae Kwan LEE ; Jun Young HUR ; Ho Sawk SAW ; Yong Kyun PARK ; Kap Soon JU ; In Soo IM ; Kap No LEE

Affiliations

+expand

Keywords

Hormone replacement therapy; Lipid metabolism; Bone metabolism; Dydrogesterone

Country

Republic of Korea

Language

Korean

Abstract

The addition of a monthly course of progesterone decrease the incidence of endometrialhyperplasia and endometrial carcinoma. The progesterones used in hormonal replacementtherapy(HRT) differ markedly in their progesteronic, androgenic and even estrogenicactivities. These characteristics may influence both symptomatic and metabolic side effects.The purpose of this study was to examine effect of bone and lipid metabolism inpostmenopausal women treated with conjugated equine estrogens plus dydrogesterone.A total 131 postmenopausal women(surgical menopause=95, natural menopause=36)and not-treated postmenopausal women(control=22) were invited to participate in thisstudy. Patients were divided into groups which had received conjugated equine estrogen(CEE)0.625 mg/day 21-day-cycle each month(n=20), CEE 0.625 mg/day plus Dydrogesterone 10mg/day 10-day-cycle each month(n=111), and no treatment control group(n=20).Serum lipid and lipoprotein(Triglyceride, Total cholesterol, High density lipoprotein, Lowdensity lipoprotein) and serum osteocalcin, urinary Deoxypyridinoline were examined in allpatients.There were no significant differences in bone and lipid metabolism between CEE andCEE plus Dydrogesterone groups.In conclusion, Dydrogesterone may be used safely in postmenopausal women withoutMetabolic side effect.