Natural Product Sciences  2016;22(3):154-161

doi:10.20307/nps.2016.22.3.154

Chemical Constituents from Leaves of Pileostegia viburnoides Hook.f.et Thoms.

Xiao Jun LI 1 2 ; Zu Zhen LIU ; Kwan Woo KIM ; Xiang WANG ; Zhi LI ; Youn Chul KIM ; Chang Soo YOOK ; Xiang Qian LIU

Affiliations

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Keywords

Pileostegia viburnoides Hook.f.et Thoms; Triterpenes; 4-epifriedelin; Coumarins; Vincosamide; Chemical constituents; Anti-neuroinflammatory

Country

Republic of Korea

Language

English

Abstract

Phytochemical investigation on the leaves of Pileostegia viburnoides Hook.f.et Thoms led to the isolation of twenty-five compounds, and their structures were identified as n-dotriacontane (1), taraxeryl acetate (2), friedelin (3), epifriedelinol (4), canophyllal (5), stigmast-4-en-3-one (6), stigmasterol (7), (24R)-5A-stigmastane-3,6-dione (8), ursolic acid (9), pomolic acid (10), umbelliferone (11), 4-epifriedelin (12), n-octatriacontanol (13), β-amyrin (14), α-amyrin (15), taraxerol (16), nonadecanol (17), friedelane (18), arachic acid (19), protocatechuic acid (20), n-pentatriacontanol (21), hexadecanoic acid (22), vincosamide (23), daucosterol (24), and skimming (25), respectively. To our best knowledge, compounds 1, 2, 12, 13, 17 - 19 and 21-23 were new within Saxifragaceae family. Compounds 15, 16, and 20 were produced from this genus for the first time. Compounds 4, 14 and 25 were first obtained from species P. viburnoides and compounds 3, 5 - 11, and 24 were achieved from the leaves of P. viburnoides for the first time. Furthermore, the anti-neuroinflammatory activity of these isolates was evaluated.