Journal of Modern Laboratory Medicine 2016;31(3):95-97

doi:10.3969/j.issn.1671-7414.2016.03.026

Expression and Its Clinical Significance of Forkhead Box J2 in Non-small Cell Lung Cancer Tissues and Paracancerous Tissues

Xiang CHEN ; Guohua TAO ; Feng ZHOU ; Ping ZHAO ; Qichang YANG ; Yi SHEN ; Xingjian CAO

Keywords

Foxj2; NSCLC; western blot; immunohistoehemical; lymphatic node metastasis

Country

China

Language

Chinese

Abstract

Objective To evaluate the expressions and its clinical significance of Foxj2 in non-small cell lung cancer (NSCLC) patients.Methods Fifty cancer tissues from patients who underwentsurgery were collected.Western blot and immunohisto-chemical methods were used to detect the expressions of Foxj2.Results Results of western blot showed that Foxj2 expres-sion in lung cancer tissue was significantly lower than adjacent tissues.The difference between the two groups was statisti-cally significant(P<0.05).Immunohistoehemical results showed that the number of Foxj2-positive cells in adjacent tissues was significantly higher than that in cancer tissues,and the expression of Foxj2 in non-lymphatic node metastasis group was higher than that in lymphatic node metastasis.The difference between the two groups was statistically significant (P<0.01).Conclusion The expressions and location of Foxj2 was related to the lymphatic node metastasis of lung cancer.This phenomenon indicates that Foxj2 may play an important role in the development of lung cancer.