Objective:To explore the relationship among carotid intima‐media thickness (IMT) ,plaque score ,plasma level of C reactive protein (CRP) and coronary artery lesion in patients with coronary heart disease (CHD) .Meth‐ods:A total of 83 CHD patients were enrolled as CHD group and 37 patients without CHD were enrolled as non‐CHD group .CHD patients received coronary angiography .According to number of diseased coronary vessels ,CHD patients were divided into single vessel coronary disease group (n=28 ,single vessel group ) ,double‐vessel coronary disease group (n=31 ,double‐vessel group) and triple‐vessel coronary disease group (n= 24 ,triple‐vessel group) . Plasma CRP level and carotid IMT were measured ,and carotid atherosclerotic plaques were classified in all groups . Results :Compared with non‐CHD group ,there were significant rise in CRP level [ (0.89 ± 0.54) mg/L vs . (3.50 ± 3.42) mg/L] and IMT [ (0.65 ± 0.27) mm vs . (1.04 ± 0.31) mm] in CHD group (P<0.05 or <0.01);Com‐pared with single‐vessel group and double‐vessel group ,the CRP level of triple‐vessel group [ (1.44 ± 1.03) mg/L , (3.71 ± 3.52) mg/L vs .5.82 ± 3.98) mg/L] significantly rose ;the percentage of carotid plaque class 3 of triple‐ves‐sel group (0% 、0% vs .25% ) significantly rose (P<0.01 all) .Conclusion:C reactive protein level and carotid intima‐media thickness significantly rise in patients with coronary heart disease ,and there are significant rise in C reactive protein level and percentage of carotid atherosclerotic plaque class 3 in patients with multi‐vessel coronary disease .