Objective To investigate the risk factors of ischemic stroke in Jiangsu Taixing population.Methods Case-control study was used in this investigation.Cases: all the diagnosed ischemic stroke patients in neurology department of Taixing People 's Hospital from 2011.9 to 2013.6.Controls: all the controls were selected randomly from community residents in Taixing city during the same period of time, according to the age and gender and ratio of 3:2.Univariate analysis and Logistic regression model was applied to analyze risk factors respectively.Results Seven hundred and seventy-seven stroke patients ( case group) and 518 controls ( control group) were brought into the study.It was preliminarily found in univariate analysis that compared with the control group, the rates of smoke, hypertension, diabetes, hyperlipidemia and the waist circumference, waist-to-hip ratio were significantly higher in the case group;while the total bilirubin level was significantly lower ( all P<0.001 ) .Logistic regression showed that smoking (OR=2.089, 95%CI:1.452-3.005), hypertension (OR=3.838, 95%CI:2.516-5.855) were risk factors of stroke in the elder population in Taixing, elevated total bilirubin level ( OR=0.281, 95%CI:0.155-0.508) was protective factor of stroke in the elder population ( all P<0.05 ).Conclusion No smoking, no hypertension history could make it less possible for stroke to occur, and total bilirubin level becomes protective factor of stroke.