Journal of Medical Biomechanics 2009;24(6):401-407

Thrombus formation in vivo

Li YANG ; Yonggang LV

Keywords

Thrombus; Mechanism; Thrombolitics; Thrombogenesis; Platelet aggregation; Shear stress

Country

China

Language

Chinese

Abstract

The mechanism of thrombus formation in living vessel wall is complex and involves a combination of blood and vessel wall properties and local flow conditions.The significance，theory and experimental tech-niques of thrombus formation in vivo were comprehensively reviewed.Particularly,the important role of signa-ling pathway and hemodynamic in thrombus formation in vivo was pointed out.The difficulty ic in vivo animal models was analyzed.Some recent new phenomena as welt as new approaches and directions worthy of in-vestigation also were summarized.