Journal of Pharmaceutical Analysis 2012;02(1):56-61

doi:10.1016/j.jpha.2011.09.013

Glassy carbon electrode modified with multi-walled carbon nanotubes sensor for the quantification of antihistamine drug pheniramine in solubilized systems

Rajeev JAIN ; Sanjay SHARMA

Keywords

Pheniramine; Sodium lauryl sulfate (SLS); Glassy carbon electrode modified with multi-walled carbon nanotubes (GCE-MWCNTs); Solubilized systems; Voltammetric quantification

Country

China

Language

Chinese

Abstract

A sensitive electroanalytical method for quantification of pheniramine in pharmaceutical formulation has been investigated on the basis of the enhanced electrochemical response at glassy carbon electrode modified with multi-walled carbon nanotubes in the presence of sodium lauryl sulfate.The experimental results suggest that the phcniramine in anionic surfactant solution exhibits electrocatalytic effect resulting in a marked enhancement of the peak current response.Peak current response is linearly dependent on the concentration of pheniramine in the range 200-1500 μg/mL with correlation coefficient 0.9987.The limit of detection is 58.31 μg/m L.The modified electrode shows good sensitivity and repeatability.