Chinese Journal of Internal Medicine 2015;54(2):122-124

doi:10.3760/cma.j.issn.0578-1426.2015.02.008

The association between angiogenin gene variations and familial amyotrophic lateral sclerosis in Chinese Han patients

Huagang ZHANG ; Yingshuang ZHANG ; Lu TANG ; Nan ZHANG ; Dongsheng FAN

Keywords

Amyotrophic lateral sclerosis,familial; DNA mutational analysis; Polymorphism,single nucleotide; Angiogenins

Country

China

Language

Chinese

Abstract

Objective To investigate effect of genetic variants in angiogenin (ANG) on the susceptibility of familial amyotrophic lateral sclerosis (FALS) in Han Chinese.Methods Thirty-one FALS families from 2009 to 2012 were collected and ANG gene was screened in the probands using PCR and direct sequencing.Results All 31 ALS families were autosomal dominant inheritance.No mutations and single nucleotide polymorphism were detectable in ANG gene in the 31 probands.Conclusion Our study suggests that ANG gene variations may be rare in Chinese Han FALS.