From April 2011 to October 2013,68 patients scheduled for complex hepatobiliary and pancreatic surgery underwent full-thickness suturing of abdominal incision with subcutaneous negative pressure drainage.There was no such complications as wound dehiscence or sinus formation.Except for 2 cases of wound infection,primary healing was achieved.Two infected cases were followed up for 1 year and there was incisional hernia.The full-thickness suturing of abdominal incision plus subcutaneous negative pressure drainage could prevent postoperative wound infection and promote wound healing.And this simple and practical approach is worthy of wider clinical application.