Chinese Journal of Immunology 2015;(6):806-808

doi:10.3969/j.issn.1000-484X.2015.06.019

Relationship of clinical outcomes and expression of microRNA-199 a/b-3 p in HCC

Lei LIU ; Shouqing LI ; Xuguang MI ; Yanqiu FANG

Keywords

Hepatocellular carcinoma; microRNA-199a/b-3p; Cum survival

Country

China

Language

Chinese

Abstract

Objective:To investigate the expression of microRNA-199a/b-3p (miR-199a/b-3p) in hepatocellular carcinoma ( HCC) tissues,and to explore the relationship with clinical outcomes. Methods: Real time quantitative PCR technique was used to measure the expression of miRNA-199a/b-3p in HCC tissues. The correlation between miR-199a/b-3p expression and the clinic pathological features of patients were analyzed. Results: Comparing with adjacent control, miRNA-199a/b-3p presented lower expressions in HCC tissues (P<0. 05);lower miR-199a/b-3p was found correlated with metastasis and poor survival. Conclusion:MiR-199a/b-3p take a crucial role in HCC metastasis and recurrence.