High-frequency oscillations are used more and more widely on localizing epileptogenic zone and evaluating outcome as the surgery on epilepsy cases are increasing and the technique of electroencephalogram (EEG) are being improved.High-frequency oscillations are recorded by intracranial electrodes on most previous studies.However,recent reports describing high-frequency oscillations on scalp EEG recordings have created significant interest.Scalp high-frequency EEG provides a safe,non-invasive and simple method for us to study the special brain electrical activity.This paper summary the clinical applications and some questions on scalp high-frequency EEG.