Autophagy is the process of removing the lysosomal and use of degradation products,which can keep the balance of protein metabolism and maintain a stable cellular environment,thus autophagy is extensively involved in various pathophysiological processes.In recent years,although there has been some progress in the molecular and regulation mechanisms of autophagy,however,the research on autophagy and nervous system diseases has only just begun.Studies of rats with brain damage have shown that injection of autophagy inhibitors reduced extent of convulsions.Therefore we put forward scientific hypothesis that autophagy is associated with brain injury and signal transduction,and autophagy may aggravate brain damage by certain signaling pathways.This article outlines the new progresses of autophagy and autophagy inhibitors,and further explore its effects on the nervous system.