Chinese Journal of Biochemical Pharmaceutics 2015;(6):176-180

Recent advance of small molecular VEGFR-2 inhibitors for cancer treatment

Ziyu GUO ; Zhaopeng LIU

Keywords

anticancer; angiogenesis; inhibitors; VEGF; VEGFR; VEGFR-2

Country

China

Language

Chinese

Abstract

Vascular endothelial growth factor receptors ( VEGFR ) belong to the receptor-type tyrosine kinase ( RTK ) super family and play important roles in tumor angiogenesis.Abnormal activation of VEGFR results in several disorders including cancer.VEGFR-2 is the major signal transducer for angiogenesis, and therefore, it becomes a good target for the inhibition of tumor development and metastasis.Nowadays, the VEGFR-based antiangiogenic therapy becomes one of the most powerful clinical strategies for cancer treatment.In this review, small molecular VEGFR-2 inhibitors are classified according to their structural features, their biological activities and current statue are briefly introduced.