International Journal of Cerebrovascular Diseases 2015;(5):374-377

doi:10.3760/cma.j.issn.1673-4165.2015.05.010

Orexin A and cerebrovascular diseases

Wei HE ; Zhiqiang SU

Keywords

Orexins; Orexin Receptors; Stroke; Brain Ischemia; Cerebral Hemorrhage; Subarachnoid Hemorrhage

Country

China

Language

Chinese

Abstract

Orexins are a class of important hypothalamic neuropeptides,including type A and B. Orexins are associated w ith numerous physiological functions, including sleep-aw akening, energy balance, endocrine and visceral functions, and they also have certain relations w ith the pathophysiological changes, such as drow siness and drug abuse. In recent years, the pathophysiological role and mechanism, as w el as the clinical significance of orexins in cerebrovascular diseases are causing concern. This article summarizes the roles of orexins and focuses on the roles of orexin A in cerebrovascular diseases.