Chinese Journal of Clinical Infectious Diseases 2015;12(3):283-286

doi:10.3760/cma.j.issn.1674-2397.2015.03.025

Research progress on hepatitis C virus-related cryoglobulinemia

Zhantao ZHU ; Fuying MA ; Junying ZHOU ; Xiaoshuang ZHOU

Keywords

Hepatitis C; Cryoglobulinemia; Pathogenesis; Interferons

Country

China

Language

Chinese

Abstract

Chronic hepatitis C virus ( HCV) infection has been reported in association with several extrahepatic complications, among which mixed cryoglobulinemia is the most documented. Clinical manifestations of HCV related cryoglobulinemia include skin lesions, glomerulonephritis, peripheral neuropathy, and widespread vasculitis.The therapy may be directed to eradicate HCV infections, suppress B-cell clonal expansion and cryoglobulin production, and ameliorate symptoms.This paper reviews the research progress on pathogenesis, clinical manifestations, diagnosis and treatment of HCV related cryoglobulinemia.