Herald of Medicine 2015;(7):952-954

doi:10.3870/yydb.2015.07.030

Preparation of Osthol Loaded Solid Lipid Nanoparticles

Jiaoting CHEN ; Miaofei WANG ; Hao HUANG ; Guoan LUO

Keywords

Osthol; Solid lipid nanoparticles; Melt-homogenization method; Preparation technics

Country

China

Language

Chinese

Abstract

Objective To study the main factors affecting the preparation of osthol ( Ost ) loaded solid lipid nanoparticies ( SLN ) . Methods The SLN were prepared by melt-homogenization method. The optimum formulation and process were selected by orthogonai design. The shape, particle size, loading capacity were investigated. Results The obtained Ost-loaded SLN were sphere or oval at a range of 100-200 nm, and were well distributed without adhesion, the loading capacity was 59. 78%. Conclusion The melt-homogenization method is available for the preparation of Ost loaded SLN.