Journal of Medical Postgraduates 2015;(6):666-669

Advances research in chromatin DNaseⅠhypersensitive sites and its transcriptional regulation function

Wenqi YU ; Yamei WANG

Keywords

DNaseⅠhypersensitive sites; High-throughput sequencing technology; Transcriptional regulation functions

Country

China

Language

Chinese

Abstract

DNaseⅠhypersensitive sites (DHSs) are regions of extreme chromatin which is highly sensitive to DNaseⅠ.Ge-nome-wide mapping DHSs is a powerful method for identifying many different types of regulatory elements within nuclear chromatin .It can help systematically resolve gene and genomic information , and the dynamic molecular mechanism of transcriptional regulation .This paper reviews the distribution of DHSs , the technology of DNase-seq and the research progress in transcriptional regulation functions of DHSs.