Chinese Journal of Gastroenterology 2015;(5):257-260

doi:10.3969/j.issn.1008-7125.2015.05.001

Immunity Mediates the Pathogenesis of Functional Dyspepsia

Xiucai FANG

Keywords

Gastrointestinal Diseases; Dyspepsia; Immunity; Eosinophils; Mast Cells; Post-Infectious Functional Dyspepsia

Country

China

Language

Chinese

Abstract

The etiology and pathogenesis of functional dyspepsia( FD)are still unknown,recent studies showed that immune responses play a mediation role in the pathogenesis of food allergy,inflammation-related and post-infectious FD. The increased and activated eosinophils in duodenal mucosa,the infiltration of inflammatory immune cells in gastric and duodenal mucosa,and the peripheral immune responses are correlated with delayed gastric emptying,decrease of sensory function of proximal stomach,visceral hypersensitivity and FD symptoms. Strategies that suppress immune response might be prospective for subset of FD patients with evidences of immune dysregulation.