Tianjin Medical Journal 2014;(12):1243-1245

doi:10.3969/j.issn.0253-9896.2014.12.026

Review the Function and Structure of Interleukin-35 and Its Function in Mediating Treg Cell Immuno-Suppression

Yongjia YAN ; Xianghui HE

Keywords

T-lymphocytes,regulatory; autoimmune diseases; immune tolerance; IL-35; iTR35 cells

Country

China

Language

Chinese

Abstract

Interleukin (IL)-35 is a new member of IL-12 family who is secreted by T regulatory cells to strongly sup?press immuno reaction directly or indirectly. There is a growing interest in the using IL-35 as a potential therapy for chronic in?flammatory , cancer and autoimmune diseases. Here we reviewed IL-35 and its function as a mediator of suppression.