Pharmaceutical Journal  2000;293(9):9-11

Synthesis and study on the hypocholesterolemia effects of N,N,N-trimethylchitosan (TMC)

Chinh Van Luu

Keywords

chitosan

Country

Viet Nam

Language

Vietnamese

Abstract

Quaternized chitosan was synthesized and structurally determined. The result showed that N,N,N-trimethylchitosan had a significant lowering cholesterol effect in blood of rats and rabbits in comparison to cholestyramine. Moreover TMC did not decrease the HDL-C (High Density Lipoprotein Cholesterol) used in treatment of arteriosclerosis.