Journal of Rheumatic Diseases  2012;19(1):51-54

doi:10.4078/jrd.2012.19.1.51

A Case of Refractory SAPHO Syndrome Treated with Etanercept.

Ye Ji KIM 1 ; Song I BAE ; Sung Jae CHOI ; Young Ho LEE ; Jong Dae JI ; Gwan Gyu SONG

Affiliations

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Keywords

SAPHO syndrome; Treatment; TNF-alpha blocker

Country

Republic of Korea

Language

Korean

Abstract

SAPHO syndrome, which has different skin changes and osteoarticular inflammation, is an acronym that stands for synovitis, acne, pustulosis, hyperostosis, and osteitis. Treatment of SAPHO syndrome includes non-steroidal anti-inflammatory drugs (NSAIDs), anti-rheumatic drugs, such as colchicines, corticosteroids and bisphosphonates, and disease-modifying agents. However, the treatment of SAPHO syndrome is controversial because it is a new clinical entity with unclear etiopathogenesis and inadequate clinical studies. We report a case with refractory SAPHO syndrome, which was successfully treated with a tumor necrosis factor (TNF)-alpha blocker.