Journal of the Korean Society of Pediatric Nephrology  2003;7(2):245-252

A Case of Posttransplant Lymphoproliferative Disease Following Renal Transplantation in a Child.

Won Kyoung JHANG 1 ; Hyewon HAHN ; Mee Jeung LEE ; Young Seo PARK ; Thad T GHIM

Affiliations

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Keywords

Posttransplant lymphoproliferative disease; EBV; Late-onset; Malignant lymphoma; Kidney transplantation

Country

Republic of Korea

Language

Korean

Abstract

Posttransplant lymphoproliferative disease(PTLD) has emerged as a potential life-threatening complication of immunosuppressive therapy after organ transplantation. The occurrence of PTLD is usually associated with an Epstein-Barr virus(EBV) infection in patients who are treated by aggressive immunosuppressive therapy. PTLD is represented by diverse manifestations ranging from reactive lymphoid hyperplasia to high grade malignant lymphoma. This is a case report of a late PTLD in a child. The patient is a 14-year-old girl, who presented as malignant lymphoma 44 months after successful renal transplantation. There was no evidence of EBV infection. On bone marrow study, many neoplastic lymphoid cells were detected. Aggressive chemotherapy for PTLD had resulted in clinical remission. However the patient expired from uncontrolled sepsis and septic shock after 77 days.