Objective To explore the effects of amiodarone on rapid ventrile rate atrial fibrillation (Af) in elder patients with acute myocardial infarction (AMI). Methods Besides the injection, an oral amiodarone was given to 96 elder patients,observing the condition of converting and maintaining of atrial fibrillation,ventricular rate controlling, blood pressure changing,mortality in 30 days and negative effects in 96 elder patients with AMI and Af. Results Eighty-two cases (84.4%) restore sinus rhythm, the cardioversion rate is 85.4%(P<0.01). 8 cases failed to cardioversion, 6 cases died . The ventricular rate were significantly lowered than before the treatment (P<0.01). All cases appeared no significant changes in blood pressure (P>0.05). Conclusion In AMI, vein plus oral application amiodarone treat the fast ventricular rate is effective and safety for patients with Af.