Acta Anatomica Sinica 2014;(3):430-436

doi:10.3969/j.issn.0529-1356.2014.03.025

Role of HOX genes in tumor genesis and development

Miaomiao NIU ; Jun ZHAN ; Hongquan ZHANG

Keywords

HOX gene; Transcription factor; Tumor; Biological regulation; Immunohistochemistry

Country

China

Language

Chinese

Abstract

HOX gene belongs to a highly conserved subgroup of the homeobox superfamily .The HOX genes constitute a family of transcription factors that play key roles in embryonic development , regulating numerous processes , such us cellular growth, differentiation, apoptosis, motility and angiogenesis.The present review shows that there is a close relationship between aberrant expression of HOX genes and malignancy .This article summarizes briofly the advances in the research on HOX genes and their roles in tumor genesis .