Acta Anatomica Sinica 2014;(3):437-440
doi:10.3969/j.issn.0529-1356.2014.03.026
Role of phosphorylation of p53 at Ser392 in cancer therapy
Jingli LIU ; Xinli SHI ; Cheng CUI ; Laifeng REN ; Wenguang ZHENG ; Mingyuan LI
Keywords
p53; Ser392; Phosphorylation; Cancer therapy; Gene mutant; Western blotting
Country
China
Language
Chinese
Abstract
Phosphorylation is the most common way of p 53 post-translational modifications .However , gaps still exist in our knowledge regarding the role and mechanism of phosphorylation of p 53 at Ser392 in carcinogenesis and cancer prevention.In the present study, we summarized the effect of phos-p53-Ser392 to wild-type and mutant p53, the regulation by DNA damage agents and protein kinase , and the significance of phosphorylation of p 53-Ser392 in cancer treatment .
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