Objective To evaluate the clinical value of plasma procalcitonin and D-dimer measurements in estima-ting the prognosis of patients with sepsis.Methods According to prognosis,68 patients with sepsis were divided in-to survival group and death group,levels of procalcitonin and D-dimer,and acute physiology and chronic health eval-uation II (APACHE II)of two groups of patients were compared,predictive value of above markers in estimating the prognosis of patients with sepsis were evaluated.Results Of 68 patients with sepsis,28 survived and 40 died, mortality was 58.82%.There were significant differences in levels of procalcitonin and D-dimer,as well as APACHE II between two groups(both P<0.05),death group were all higher than survival group.Procalcitonin and D-dimer level were positively correlated with APACHE II score(P<0.05).Conclusion Procalcitonin,D-dimer level and APACHE II score can be used to evaluate condition of patients with sepsis as well as the prognosis of dis-ease.