Dementia and Neurocognitive Disorders  2014;13(3):79-82

doi:10.12779/dnd.2014.13.3.79

Non-paraneoplastic Autoantibody-negative Limbic Encephalitis Characterized by Mild Memory Impairment: A Case Report.

Sangwoo HAN 1 ; Jaejeong JOO ; Jinho KANG ; Sang Won HA ; Youngsoon YANG

Affiliations

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Keywords

Limbic encephalitis; Memory impairment; Non-paraneoplastic; Autoantibody negative

Country

Republic of Korea

Language

Korean

Abstract

Encephalitis that primarily involves limbic system structures such as the hippocampus and parahippocampal gyrus has been described in early papers, most commonly characterized by a subacute progressive impairment of short-term memory, psychiatric features and seizures. While these findings might be caused by viral infections or systemic autoimmune disorders, many patients with limbic encephalitis have an immune-mediated etiology (paraneoplastic or not) characterized with serum or CSF antineuronal antibodies. This case reports about non-paraneoplastic autoantibody-negative limbic encephalitis in which there are no detection of antigens and no evidence of tumors.