56 girls with central precocious puberty were divided into the depression group and non-depression group according to the short mood and feelings questionnaire;then the levels of basic estradiol ( E2 ) , follicle stimu-lating hormone ( FSH ) and luteinizing hormone ( LH ) at various time points were compared between the two groups. The E2 level of the non-depression group was higher compared with the depression group ( P <0.01 ) . However, the significant difference of FSH and LH between the two groups was not discovered (P>0.05). The re-sults above demonstrated a negative correlation between depression and the E2 level of precocious puberty girls.