Acta Laboratorium Animalis Scientia Sinica 2014;(2):95-110

doi:10.3969/j.issn.1005-4847.2014.02.0020

Research progress of tree shrew models of viral hepatitis and modeling strategy

Yiquan PANG ; Yue FENG ; Xiaomei SUN ; Li LIU ; Jiejie DAI ; Xueshan XIA

Keywords

Viral hepatitis; Hepatitis B virus; Hepatitis C virus; Tree shrews; Animal model

Country

China

Language

Chinese

Abstract

Viral hepatitis is a major liver disease caused by virus infection .Viral hepatitis is popular in China , mainly caused by hepatitis B and hepatitis C viruses .Experimental animal model is a necessary platform for the research on mechanism of viral infection and pathogenicity , for treatment and vaccine development .Up to date, a great progress in the development of viral hepatitis animal models has been achieved in spite of the most of findings are limited to hepatitis B and C.Here, we summarize the recent findings of viral hepatitis animal models , focusing on the tree shrew animal model and its modeling strategy .