Chinese Journal of Gastroenterology 2014;(5):305-308

doi:10.3969/j.issn.1008-7125.2014.05.013

Advances in Study on Bile Reflux Gastritis

Ying WEI ; Shigang DING

Keywords

Bile Reflux Gastritis; Duodenogastric Reflux; Bile Acids and Salts; Diagnosis; Therapy

Country

China

Language

Chinese

Abstract

Bile reflux gastritis (BRG)has been recognized as a chemical gastropathy due to excessive duodenogastric reflux (DGR).Abnormalities in pyloric anatomic structure,as well as antropyloric and duodenal dysmotility are considered to be implicated in the occurrence of pathologic DGR.Bile acid may induce apoptosis of gastric mucosal cells,and high concentration of bile acid plays a crucial role in the induction of intestinal metaplasia in stomach.In this review article, advances in study on BRG,including the mechanisms of DGR,the pathogenic effect of bile acid on gastric mucosa,and the diagnosis and treatment of BRG were summarized.