Chinese Journal of Gastroenterology 2014;(5):301-304

doi:10.3969/j.issn.1008-7125.2014.05.012

Advances in Study on JAK/STAT3 Signaling Pathway and its Role in Gastrointestinal Diseases

Xiang XUE ; Shinan NIE

Keywords

JAK/STAT3 Signaling Pathway; Gastrointestinal Diseases; Stomach Neoplasms; Colorectal Neoplasms; Inflammatory Bowel Disease

Country

China

Language

Chinese

Abstract

JAK/STAT3 signaling pathway exists in various organs and tissues and mediates multiple biological processes including cell proliferation,differentiation,migration,apoptosis and immunoregulation.Recently,it has been revealed that this pathway plays an important role in gastrointestinal diseases,promoting tumor growth,angiogenesis and inhibiting apoptosis in gastric and colorectal cancers,and being implicated in the pathogenesis of inflammatory bowel disease.Inhibitors targeting JAK/STAT3 pathway showed promising outcome in some disease models.In this review article,the advances in study of abovementioned issues were summarized.