Intestinal trefoil factor (ITF or TFF3) is a member of trefoil factor family which is most studied , mainly in the in-testinal tract .TFF3 plays an important role in gastrointestinal mucosal protection and epithelial repair .Action mechanism includes in-teraction with mucin, migration, anti-apoptosis, angiogenesis, immune regulation, interaction with its receptor, etc.Recombinant TFF3 has been approved as a national drug and its therapeutic indications for repair mucosa , prevention and treatment of gastrointesti-nal ulcers and inflammation .Furthermore, the classic TFF3 receptor and signaling pathway is highly valuable to make TFF 3 become an effective treatment for gastrointestinal injury disease .