Chinese Journal of Pharmacology and Toxicology 2014;(2):279-282

doi:10.3867/j.issn.1000-3002.2014.02.023

Probabilistic risk assessment of the dietary exposure of Chinese population to acephate using margin of exposure

Nannan YI ; Hui WU ; Xinya YAO ; Minxian ZHAO ; Zhengying CAO ; Cannan WANG

Keywords

acephate; dietary exposure risk; margin of exposure

Country

China

Language

Chinese

Abstract

OBJECTIVE Calculate the dietary exposure and exposure risk of Chinese consumers to acephate,using the margin of exposure method.METHODS Determine the bench mark dose of acephate by 21 -day gavage experiment of rats.According to the data from the 2002 National Diet and Nutrition Survey,the 2000 -2006 national food conta mination monitoring program,the 2005 -2006 export monitoring data of customs,calculate the dietary exposure of Chinese consumers to acephate by probabilistic assessment.Estimate the exposure risk by co mparing the margin of exposure with 100. RESULTS The bench mark dose of acephate was 0.75 mg·kg -1 ,the BMDL was 0.51 mg·kg -1 .The exposure of children was higher than that of adults.The proportion at risk of group 1 -6 y,7 -17 y and 18 y or higher was 5%,1 % and 0.1 %,respectively.CONCLUSION So me consumers was of dietary exposure risk to acephate.The high exposure of children should be of great concern.