Journal of Practical Stomatology 2014;(2):277-279

Significances of epithelial-mesenchymal transition and TGF-β1 expression in oral carcinoma

Xia WANG ; Shuhua WU ; Peiyuan WANG ; Yuhong ZHU

Keywords

Epithelial-mesenchymal transition; TGF-β1; Metastasis; Oral carcinoma

Country

China

Language

Chinese

Abstract

Immunohisto-chemical S-P method was used to examine the expression of E-cadherin,Vimentin and TGF-β1 in 54 cases oral carcinoma and 10 cases of normal oral mucosa.The positive rates of the expression of E-cadherin,Vimentin and TGF-β1 were 55.6%, 33.33% and 59.3%,respectively in oral carcinoma group(vs normal oral mucosa,P <0.05).The expression of TGF-β1 was correlated with lymph node metastasis,and showed significant positive correlation with Vimentin.Epithelial-mesenchymal transition may promote inva-sion and metastasis of oral carcinoma,and TGF-β1 promotes EMT.