[Objective] To discuss the nursing to the common complications in perioperational period of lung cancer treated with ultrasonic guidance transdermal radiofrequency ablation(RFA). [Method] 12 cases of peripheral lung cancer treated with ultrasonic guidance transdermal RFA, took active mental nursing, closely cooperated in operation, strictly observed the disease condition after operation, had good nursing of perioperational period, and were strengthened on observation of complications and prevention. [Result] 12 cases had smooth operation, part of them had pain at puncture spot, fever, little aerothorax and hydrops, with blood in sputum at cough, and were relieved timely with active observation and clinical nursing, without other severe complications, final y they were discharged from hospital upon recovery, without death in perioperational period. [Conclusion] The ultrasonic guidance RFA is a safe and effective method to treat peripheral lung cancer with little invasion; the nursing point is to closely observe disease condition before and after operation, and do wel general nursing.