Objective To investigate the optimal extraction process of Jiangtang Tongluo Granule. Methods The orthogonal design was used in the extraction, according to the yield rate and content of paeoniflorin, with the volume of water, extraction times and extraction time as factors. The content of paeoniflorin was detected by HPLC method to determine the best extraction technology. Results The optimal water extracting technology of Jiangtang Tongluo Granule was performed by 1 h extraction for 3 times, with 10-fold volume of water. Conclusion The process is stable, feasible and reasonable, and provides a foundation for the further production and quality control.