Military Medical Sciences 2014;(1):48-52

doi:10.7644/j.issn.1674-9960.2014.01.013

Single-nucleotide polymorphisms in DNA repair genes APE1 and XRCC1 and suscep-tibility to hepatocellular carcinoma and their correlation with sensitivity of platinum chemotherapy in HCC

Zhuangwei FANG ; Zhu LIANG ; Ning WU ; Chun QIU ; Fuhuang LIN ; Bo YUAN ; Yonghong PENG ; Yong FU ; Weiping ZHOU ; Kailun ZHOU ; Xianhe XIE

Keywords

polymorphism,gene; hepatocellular carcinoma; susceptibility; platinum drug sensitivity

Country

China

Language

Chinese

Abstract

Objective To investigate the relationship between APE1, XRCC1 gene polymorphisms and hepatocellular carcinoma(HCC) susceptibility and to explore the correlation of APE1, XRCC1 gene polymorphisms with the sensitivity to platinum-based drugs .Methods Seventy-eight HCC patients and 80 controls were selected .By PCR and RFLP , the single nucleotide polymorphism of APE1 Asp148Glu and XRCC1 Arg194Trp genes and the susceptibility of HCC or platinum drug sensitivity were analyzed.Results The Glu/Glu genotype of APE1 could increase in the risk of HCC by 7.21 times (95%CI:1.325-29.109) (P<0.05).APE1 and XRCC1 gene polymorphisms could also affect the platinum drug resistance of HCC patients.Conclusion APE1 Asp148Glu is correlated with the susceptibility to HCC .APE1 and XRCC1 genes can be considered a target for therapy to improve the sensitivity of HCC platinum drugs .