International Journal of Cerebrovascular Diseases 2013;21(9):693-696

doi:10.3760/cma.j.issn.1673-4165.2013.09.006

Apolipoprotein E gene polymorphism and ischemic stroke

Yun YANG ; Hong XU

Keywords

Stroke; Brain Ischemia; Apolipoproteins E; Polymorphism,Genetic

Country

China

Language

Chinese

Abstract

Apolipoprotein E (ApoE) has gene polymorphism (ε2,ε3,and ε4).It has been confirmed that ApoE structural and functional abnormlities are closely associated with the hyperlipidemia,formation of atherosclerosis,and its severity,while both hyperlipidemia and atherosclerosis are the risk factors for ischemic stroke.In recent years,although the relationship between the ApoE gene polymorphism and ischemic stroke has been extensively studied,the conclusions are not consistent.This article reviews the correlation studies between the ApoE gene polymorphism and ischernic stroke.