Objective: To investigate the HbA1c and urinary albumin in early diagnosis of diabetic nephropathy in type 2 diabetes mellitus value. Methods:In 42 patients with diabetes and fasting blood glucose (FBG), glycosylated hemoglobin (HbAlc), microalbuminuria (M-ALB), cholesterol (CHo), glycerin three greases (TG), high density lipoprotein cholesterol with alcohol (HDL-C), low density lipoprotein cholesterol (LDL-C), blood routine determination, and the results compared with healthy controls. According to the determination result of glycosylated hemoglobin for low value group (HbAlc<6.79%), median group (HbAIc 6.8%~10%), higher values in the group (HbAlc>10.1%). Results:The diabetes patient's HbAIc, FBG, CHo, TG, LDL-C concentrations were significantly higher than healthy control group, the serum HDL-C concentration was significantly lower than that of the control group. The difference was statistically significant. With the increase of HbAIc. FBG, m-ALB increased. Conclusion: Diabetic nephropathy is associated with increased HbAlc. Dyslipidemia can increase in microvascular lesions in diabetic nephropathy risk. M-ALB diabetes is early glomerular injury markers. I can be used as the screening index of chronic nephropathy. Combined detection of glycosylated hemoglobin of diabetes and microalbuminuria in favor of diabetic nephropathy early detection, delay the progression of diabetic nephropathy.