Objective: To propose essential thought for the disease pricing and to provide theoretical and methodological references for promoting disease pricing in China. Methods: Utilizing literature research method and theoretical deduction method are used to comb and analyze the theory of disease pricing theory. Results: On the basis of the research for disease cost calculation, key process of pricing like disease groups is proposed, benchmark disease and relative weight of diseases price and draws into degree of risk factors and technical difficulties. At the same time, it proposes the manipulation of cases outside the lines and pricing adjustment system. Conclusion: The research is scientific, prospective and innovative.