International Journal of Cerebrovascular Diseases 2013;21(9):711-716

doi:10.3760/cma.j.issn.1673-4165.2013.09.010

Membrane-associated guanylate kinases and cerebral ischemia

Qingjie LI ; Yun XU

Keywords

Brain Ischemia; Guanylate Kinase; Membrane Proteins; Receptors,N-Methyl-D-Aspartate; Post-Synaptic Density

Country

China

Language

Chinese

Abstract

Membrane-associated guanylate kinases (MAGUKs) is a class of postsynaptic density proteins (PSDs) in the postsynaptic dense of the postsynaptic membrane,including PSD-95,SAP-102,PSD-93,and SAP-97.MAGUK family members contain several protein binding sites,and these special binding sites are responsible for mediating a variety of signal transduction.MAGUKs participate in the occurrence and development mechanisms in central nervous system diseases,and has become a topic of general interest of neuroscience.This article briefly reviews the roles of MAGUKs in ischemic brain injury.