International Journal of Pediatrics 2013;40(5):518-521

doi:10.3760/cma.j.issn.1673-4408.2013.05.022

Advances of the LHX3 and LHX4 LIM-homeodomain transcription factors

Limin WANG ; Guiling LI

Keywords

LHX3; LHX4; Structure; Function; Expression; Mutation

Country

China

Language

Chinese

Abstract

The LHX3 and LHX4 LIM-homeodomain transcription factors play essential roles in pituitary gland.Nervous system developments play certain roles in some cancers,leukemia,and deafness disease.Mutations in the genes encoding these regulatory proteins are closely associated with combined hormone deficiency diseases in human and animal models,and related to nervous system defect,tumors,leukemia and deafness.Analysis of these diseases and the biochemical properties of the LHX3 and LHX4 protein will facilitate a better understanding of the pathogenesis of these diseases.LHX3 and LHX4 are reviewed in this paper.