Chinese Pediatric Emergency Medicine 2013;20(5):535-537

doi:10.3760/cma.j.issn.1673-4912.2013.05.033

Signal transducers and activators of transcription(STAT) family and pathogenesis of asthma

Nan ZHANG ; Simin WAN ; Suwan ZHANG

Keywords

STAT family; Bronchial asthma

Country

China

Language

Chinese

Abstract

Bronchial asthma(asthma for short) is a chronic inflammatory disease of the lung,which is involved with various cells and cytokines.Now,the related genes of asthma is not well-known yet.But research shows that there are related genes to airway hyperreactivity,IgE regulation and atopic reaction.These genes play an important role in asthma.In recent years,it is recognized that STAT family plays an important role in inflammatory and immunological diseases.In this article the role of STAT family played in asthma pathogenesis will be reviewed.