Objective To discuss the clinical effect of entecavir in treatment of hepatitis B-related nephritis. Methods 28 patients with hepatitis B-related nephritis diagnosed in our hospital through needling biopsy of kidney from 2009 to 2012 were selected in this study. All patients were given oral entecavir, besides conprehensive treatments,including potassium aspartate and diammonium glycyrrhizinate. The treatment course was three months. We observed and analyzed patients' serum glutamic pyruvic transaminase, serum albumin and urine protein within 24 hours after two treatment courses.Results After one treatment course, the overall effective rate was 82.14%. Two courses later, the overall effective rate was 96.43%. Patients' serum glutamic pyruvic transaminase, serum albumin and urine protein within 24 hours after two treatment courses had significant differences with those before treatment's,the difference had statistical significance ( <0.05),but serum creatinine had no significant change after treatment. Conclusion Entecavir has significant curative effect on hepatitis B-related nephritis.