Annals of Laboratory Medicine  2012;32(1):95-98

doi:10.3343/alm.2012.32.1.95

CD5-negative Blastoid Variant Mantle Cell Lymphoma with Complex CCND1/IGH and MYC Aberrations.

Yoonmi SEOK 1 ; Juwon KIM ; Jong Rak CHOI ; Yu Ri KIM ; Seo Jin PARK ; Sue Jung KIM ; Jaewoo SONG ; Kyung A LEE

Affiliations

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Keywords

Mantle cell lymphoma; CCND1; MYC

Country

Republic of Korea

Language

English

Abstract

The coexistence of CCND1/IGH and MYC rearrangements in mantle cell lymphoma (MCL) is a rare finding associated with a very poor prognosis. In this study, a patient with blastoid variant (MCL) is reported. The disease was clinically aggressive and refractory to chemotherapy, and the patient only survived for 1 month following diagnosis. Conventional cytogenetic study, FISH, and multicolor FISH (mFISH) demonstrated the involvement of the BCL1/CCND1 locus in a complex translocation, t(3;11)(q25;p15)t(11;14)(q13;q32). In addition, subclonal abnormalities in the 8q24 region, manifested as a t(8;14)(q24;q32)/MYC rearrangement, were identified. To the best of our knowledge, this is the first MCL case in Korea bearing these complex genomic aberrations.