Immunological Journal 2001;(2):107-109

doi:10.3969/j.issn.1000-8861.2001.02.009

Study of gastroenteric mucosa immune responses in Balb／c mice by oral immunization with helicobacter pylori

Dongshui LU ; Changqing YU ; Quangming ZOU

Country

China

Language

Chinese

Abstract

Objective　To study the mucosa immune responses of gastric and intestinal mucosa in Balb／c mice administered orally with Hp sonicate and mucosal adjuvant（LT）．Methods　The changes of antigen specific AFC in gastric and intestinal mucosa were detected by ELISPOT assay． Results　The numbers of sIgA and IgG AFC rise significantly in PP and gastric mucosa， especially the numbers of sIgA-AFC， significant differences were observed between two immunized groups and the control． Conclusions　Locally synthesized specific sIgA antibodies contribute to immunity against gastric helicobacter infection．