Soonchunhyang Medical Science  2012;18(1):66-69

Patient with Malignant Granular Cell Tumor Treated with Sunitinib Malate.

Su Jin LEE 1 ; Ji Hyun KIM ; Hyun Wook CHO ; Gyeong Jae NA ; Han Jo KIM ; Sang Byung BAE ; Kyu Taek LEE

Affiliations

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Keywords

Malignant; Granular cell tumor; Sunitinib

Country

Republic of Korea

Language

Korean

Abstract

Malignant granular cell tumors (MGST) are extremely rare, high-grade sarcoma of schwann cell origin. They often metastasize and are associated with short survival. We described a patient with recurred MGST after wide marginal excision followed by chemotherapy. The histologic findings revealed relapsed MGST containing rich vascular structure. The patient was treated with sunitinib malate (50 mg/day) for three weeks. Because sunitinib malate has a potent antiangiogenic property, we surmised that it might be effective against this type of malignancy. However, he died due to progression of tumor after six weeks. Here, we report it along with the corresponding literature.